Medicines Co. Licenses Rights to Cholesterol Drug

The drug, known as ALN-PCS, inhibits a protein in the body known as PCSK9. Such drugs might one day be used to treat millions of people who do not achieve sufficient cholesterol-lowering from commonly used statins, such as Lipitor.

The Medicines Company will pay $25 million initially and as much as $180 million later if certain development and sales goals are met, under the deal expected to be formally announced Monday. It will also pay Alnylam, which is based in Cambridge, Mass., double-digit royalties on global sales.

That is small payment for a drug with presumably a huge potential market, probably reflecting that Alnylam is still in the first of three phases of clinical trials, well behind some far bigger competitors.

The team of Sanofi and Regeneron Pharmaceuticals is already entering the third and final stage of trials with their PCSK9 inhibitor, as is Amgen. Pfizer and Roche are in midstage trials.

ALN-PCS is different from the other drugs. It uses a gene-silencing mechanism called RNA interference, aimed at shutting off production of the PCSK9 protein. The other drugs are proteins called monoclonal antibodies that inhibit the action of PCSK9 after it has been formed.

Alnylam and the Medicines Company hope that turning off the faucet, as it were, will be more efficient than mopping the floor, allowing their drug to be given less frequently and in smaller amounts.

But that has yet to be proved. No drug using RNA interference has reached the market.

The Medicines Company, based in Parsippany, N.J., generates almost all of its revenue from one product — Angiomax, an anticlotting drug used when patients receive stents to open clogged arteries.

Dr. Clive A. Meanwell, chief executive of the company, said that PCSK9 inhibitors are likely to be used at first mainly by patients with severe lipid problems under the care of interventional cardiologists, the same doctors who use Angiomax. “It really is quite adjacent to what we do,” he said.

The Medicines Company licensed Angiomax from Biogen Idec, where the drug was invented and initially developed under a team led by Dr. John M. Maraganore, who is now the chief executive of Alnylam.

“It’s a bit like getting the band back together,” Dr. Maraganore said.

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U.S.-Mexico trade war over tomatoes appears to have been averted

American and Mexican tomato growers appear to have avoided a trade war — the U.S. Commerce Department has released a draft of an agreement governing the price of tomato imports from Mexico.

U.S. growers in Florida had accused their Mexican counterparts of selling their tomatoes below fair market value, a practice known as dumping.

The new agreement, which sets a minimum wholesale price for tomatoes, would replace a trade pact that went into effect 17 years ago.

Francisco Sanchez, the undersecretary of commerce for international trade, said in a statement Saturday that the agreement puts in place "robust enforcement that will allow American workers and the U.S tomato industry to compete on a level playing field."

In the last decade, U.S. growers found themselves competing heavily with Mexico. That country's exports of tomatoes to the U.S. reached $1.81 billion in 2011, more than quadruple the $412 million in 2000.

Eager to continue exports and sales of their tomatoes, Mexican tomato growers and importers worked with Commerce Department officials on drafting an agreement.

The plan, open to public comment until Feb. 11, would raise the wholesale price for tomatoes and strengthen anti-dumping enforcement.

One provision of the agreement, expected to take effect March 4, creates a reporting mechanism to monitor the price of production by Mexican growers.

Martin Ley, a Mexican tomato grower involved in the negotiations, said the agreement was made possible by steep concessions on the part of Mexican tomato producers.

"Getting to this moment no doubt required significant compromise by the Mexican growers," he said in a statement. "Even though no dumping or injury to the U.S. industry was demonstrated by our competitors, over the last year our growers worked with our government to overhaul the whole Mexican industry, broaden the coverage and develop tough enforcement schemes.

"While concessions on price will impose hardships on our industry, we are hopeful that over the long run we will be able to continue to supply the United States with what are acknowledged to be the best tomatoes in the market."

Late last month, a study, paid for by a Mexican tomato trade group, predicted that the price of winter tomatoes would have doubled if Mexican imports were excluded from the U.S. market. The study, released by the Fresh Produce Assn. of the Americas, projected that the price of hothouse round tomatoes, for instance, would have risen from $2.02 a pound to almost $4 a pound.

U.S. growers appeared to back the agreement but held firm to their assertion that Mexico was dumping its tomatoes.

With the agreement, "we're hopeful and optimistic that we'll be able to compete under fair trade conditions," Edward Beckman, president of Certified Greenhouse Farmers, said in a statement. "Much work remains to have the agreement fully and faithfully implemented, and continuous monitoring and enforcement will be critical."

ricardo.lopez2@latimes.com

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Noted sniper shot dead at Texas gun range

GLEN ROSE, Texas—

Former Navy SEAL and “American Sniper” author Chris Kyle was fatally shot along with another man Saturday on a Texas gun range, a sheriff told local newspapers.

Erath County Sheriff Tommy Bryant said Kyle, 38, and a second man were found dead at Rough Creek Lodge's shooting range west of Glen Rose, according to the Fort Worth Star-Telegram and Stephenville Empire-Tribune. Glen Rose is about 50 miles southwest of Fort Worth.

Bryant did not immediately return phone calls to The Associated Press seeking comment late Saturday and early Sunday. A woman who answered the phone at the lodge where the shooting occurred declined comment and referred calls to the sheriff's office.

Investigators did not immediately release the name of the second victim, according to the newspapers.

Witnesses told sheriff's investigators that a gunman opened fire on the men around 3:30 p.m. Saturday, then fled in a pickup truck belonging to one of the victims, according to the Star-Telegram. The newspapers said a 25-year-old man was later taken into custody in Lancaster, southeast of Dallas, and that charges were expected.

Lancaster police did not immediately return calls for comment.

The motive for the shooting was unclear.

Kyle wrote the best-selling book, “American Sniper: The Autobiography of the Most Lethal Sniper in U.S. Military History,” detailing his 150-plus kills of insurgents from 1999 to 2009.

Kyle was sued by former Minnesota Gov. Jesse Ventura over a portion of the book that claims Kyle punched Ventura in a 2006 bar fight over unpatriotic remarks. Ventura says the punch never happened and that the claim by Kyle defamed him.

Kyle had asked that Ventura's claims of invasion of privacy and “unjust enrichment” be dismissed, saying there was no legal basis for them. But a federal judge said the lawsuit should proceed. Both sides were told to be ready for trial by Aug. 1.

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Stevie Wonder headlines pre-Super Bowl concert

NEW ORLEANS (AP) — Applause and approval greeted Stevie Wonder as thousands stood for hours to hear his pre-Super Bowl concert that also featured guitarist Gary Clark Jr.

Escorted on stage late Saturday by his daughter and backup singer Aisha Morris, Wonder performed several of his hits, including his opening song, "How Sweet It Is (To Be Loved By You)."

That was followed by "Master Blaster," Michael Jackson's "The Way You Make Me Feel," and Wonder's own "Higher Ground."

The 62-year-old Rock and Roll Hall of Fame member headlined the event outdoor event held near the Wyndham Riverfront Hotel on the eve of Sunday's game between the Baltimore Ravens and the San Francisco 49ers.

Thousands packed a tent set up on a parking lot across the street from the hotel to hear Wonder, Clark, R&B artist Janelle Monae and DJ Martin Solveig.

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Concerns About A.D.H.D. Practices and Amphetamine Addiction

Before his addiction, Richard Fee was a popular college class president and aspiring medical student. "You keep giving Adderall to my son, you're going to kill him," said Rick Fee, Richard's father, to one of his son's doctors.

VIRGINIA BEACH — Every morning on her way to work, Kathy Fee holds her breath as she drives past the squat brick building that houses Dominion Psychiatric Associates.

Andrea Mohin/The New York Times

MENTAL HEALTH CLINIC Dominion Psychiatric Associates in Virginia Beach, where Richard Fee was treated by Dr. Waldo M. Ellison. After observing Richard and hearing his complaints about concentration, Dr. Ellison diagnosed attention deficit hyperactivity disorder and prescribed the stimulant Adderall.

It was there that her son, Richard, visited a doctor and received prescriptions for Adderall, an amphetamine-based medication for attention deficit hyperactivity disorder. It was in the parking lot that she insisted to Richard that he did not have A.D.H.D., not as a child and not now as a 24-year-old college graduate, and that he was getting dangerously addicted to the medication. It was inside the building that her husband, Rick, implored Richard’s doctor to stop prescribing him Adderall, warning, “You’re going to kill him.”

It was where, after becoming violently delusional and spending a week in a psychiatric hospital in 2011, Richard met with his doctor and received prescriptions for 90 more days of Adderall. He hanged himself in his bedroom closet two weeks after they expired.

The story of Richard Fee, an athletic, personable college class president and aspiring medical student, highlights widespread failings in the system through which five million Americans take medication for A.D.H.D., doctors and other experts said.

Medications like Adderall can markedly improve the lives of children and others with the disorder. But the tunnel-like focus the medicines provide has led growing numbers of teenagers and young adults to fake symptoms to obtain steady prescriptions for highly addictive medications that carry serious psychological dangers. These efforts are facilitated by a segment of doctors who skip established diagnostic procedures, renew prescriptions reflexively and spend too little time with patients to accurately monitor side effects.

Richard Fee’s experience included it all. Conversations with friends and family members and a review of detailed medical records depict an intelligent and articulate young man lying to doctor after doctor, physicians issuing hasty diagnoses, and psychiatrists continuing to prescribe medication — even increasing dosages — despite evidence of his growing addiction and psychiatric breakdown.

Very few people who misuse stimulants devolve into psychotic or suicidal addicts. But even one of Richard’s own physicians, Dr. Charles Parker, characterized his case as a virtual textbook for ways that A.D.H.D. practices can fail patients, particularly young adults. “We have a significant travesty being done in this country with how the diagnosis is being made and the meds are being administered,” said Dr. Parker, a psychiatrist in Virginia Beach. “I think it’s an abnegation of trust. The public needs to say this is totally unacceptable and walk out.”

Young adults are by far the fastest-growing segment of people taking A.D.H.D medications. Nearly 14 million monthly prescriptions for the condition were written for Americans ages 20 to 39 in 2011, two and a half times the 5.6 million just four years before, according to the data company I.M.S. Health. While this rise is generally attributed to the maturing of adolescents who have A.D.H.D. into young adults — combined with a greater recognition of adult A.D.H.D. in general — many experts caution that savvy college graduates, freed of parental oversight, can legally and easily obtain stimulant prescriptions from obliging doctors.

“Any step along the way, someone could have helped him — they were just handing out drugs,” said Richard’s father. Emphasizing that he had no intention of bringing legal action against any of the doctors involved, Mr. Fee said: “People have to know that kids are out there getting these drugs and getting addicted to them. And doctors are helping them do it.”

“...when he was in elementary school he fidgeted, daydreamed and got A’s. he has been an A-B student until mid college when he became scattered and he wandered while reading He never had to study. Presently without medication, his mind thinks most of the time, he procrastinated, he multitasks not finishing in a timely manner.”

Dr. Waldo M. Ellison

Richard Fee initial evaluation

Feb. 5, 2010

Richard began acting strangely soon after moving back home in late 2009, his parents said. He stayed up for days at a time, went from gregarious to grumpy and back, and scrawled compulsively in notebooks. His father, while trying to add Richard to his health insurance policy, learned that he was taking Vyvanse for A.D.H.D.

Richard explained to him that he had been having trouble concentrating while studying for medical school entrance exams the previous year and that he had seen a doctor and received a diagnosis. His father reacted with surprise. Richard had never shown any A.D.H.D. symptoms his entire life, from nursery school through high school, when he was awarded a full academic scholarship to Greensboro College in North Carolina. Mr. Fee also expressed concerns about the safety of his son’s taking daily amphetamines for a condition he might not have.

“The doctor wouldn’t give me anything that’s bad for me,” Mr. Fee recalled his son saying that day. “I’m not buying it on the street corner.”

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Love, money and the online dating industry

At the heart of the new book "Love in the Time of Algorithms" is a philosophical question: does the billion-dollar dating industry, whose currency is the perpetual promise of new relationships, signal the death of commitment?

It is the question posed to Sam Yagan, chief executive of free dating website OkCupid, by the book's author, Dan Slater. "That's really a point about market liquidity," replies Yagan, a graduate of Harvard University and Stanford Business School, and a self-confessed "math guy" who says he knows nothing about dating.

Justin Parfitt, a British dating entrepreneur, answers the question more bluntly. The industry is thinking: Let's keep this customer coming back to the site as often as we can, he said, "and let's not worry about whether he's successful. There's this massive tension between what would actually work for you, the user, and what works for us, the shareholders. It's amazing, when you think about it. In what other industry is a happy customer bad for business?"

These responses represent the dissonance between the romantic ideal of love held by many customers and the approach of the entrepreneurial nerds who set up the match­making sites. The disparity is well drawn in this lively book by Slater, a former legal affairs reporter for the Wall Street Journal, who had racked up quite a few of his own cyber dates by age 31, following the demise of a long-term relationship.

A book on the dating industry would be soulless without tales of the customers — the cyber daters. Published by Current, "Love in the Time of Algorithms: What Technology Does to Meeting and Mating" is strewn with stories of blossoming romances, bed-hoppers and borderline sociopaths.

There is Carrie, a single mom in New York, who clicks the box for "full figured," saying that while she is bigger than Kim Kardashian, she is not as big as "big and beautiful." (In the search for love, these things matter.) After several false starts with men who find the "kid thing" a sticking point, Carrie meets her match in a Puerto Rican computer technician who's an atheist.

There is also Jacob in Oregon, who knows he can afford to take things slow with the pharmacist because he can always have sex with another online date. Or, as he likes to think of it: "There's always a pepperoni pizza in the trunk."

The writer delves into his own personal history — his parents met in the 1960s through a pioneering computer dating service. His father's comments, that "these days they're all over the Internet. I think they're mostly for desperate people, though," indicate the stigma that has dogged the industry.

Slater's account of the history of the cyber dating industry — from huge clunky old computers to modern complex computer algorithms — is well detailed. And he brings out the fierce rivalry between free and paid-for sites and the new possibilities for finding a date across the street using smartphones and innovative "freemium" sites.

The stated aim of this book is how online dating is "remaking the landscape of modern relationships," which is an ambitious goal for 240 pages. The sweep is huge: Nigerian scammers preying on the lonely; paunchy middle-aged men trafficking poor young South American and Russian women; math geeks competing for a share of the love market; and adult babies seeking matronly diaper-changers.

The author also brandishes so many ideas — a bit of behavioral economics here, a bit of biological determinism there — that it is hard to focus when so much is competing for the reader's attention. It is a dizzying attempt to demonstrate the author's mastery of the zeitgeist.

In the final chapter, Slater writes that he has tried to avoid "passing judgment on all the many behaviors, new and old, facilitated by the date-o-sphere". Yet this well-reported romp through the digital love marketplace would have benefited from a slightly more domineering author.

Emma Jacobs is a columnist for the Financial Times of London, in which this review first appeared.

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Doctor who admitted dealing drugs to get his license back

A West Hollywood psychiatrist who pleaded guilty to felony drug dealing after pills he prescribed turned up for sale on Craigslist will be able to get his medical license back in a year under an agreement announced Friday by the Medical Board of California.

The sanction, though harsh by board standards, allows Nathan Kuemmerle, 40, a former methamphetamine user, to treat patients again as soon as next February.

As a result of the criminal charges, Kuemmerle had lost his privilege to prescribe controlled substances and must apply to the U.S. Drug Enforcement Administration if he wants it restored. Kuemmerle agreed to undergo random drug testing, enroll in a physician ethics class and seek psychological counseling, among other conditions.

Kuemmerle was featured in a Dec. 30 Times report on the state's failure to use its vast prescription drug database to identify reckless prescribing by physicians.

In 2009, Kuemmerle was the state's most prolific prescriber of Adderall, a widely abused stimulant, records show. His prescribing drew scrutiny only after Redondo Beach narcotics detectives arrested a suspected drug dealer peddling Adderall pills on Craigslist. The suspect identified Kuemmerle as the source of the prescriptions.

Two months later, a second suspected drug dealer arrested in Arizona also pointed authorities to Kuemmerle. When drug agents checked the state's prescription drug database, known as CURES, they discovered that in 2009 Kuemmerle prescribed nearly four times as many of the highest-dose Adderall pills as the No. 2 doctor on the list, records show. Additionally, records show, he was the state's No. 2 prescriber of the most highly controlled narcotic painkillers.

Kuemmerle was arrested and pleaded guilty in 2011 to drug dealing and was sentenced to three years' probation.

Federal agents had alleged that Kuemmerle was selling prescriptions to people he had never seen, much less examined, records show. Kuemmerle wrote an average of 15 prescriptions per day for controlled substances over a four-year period, a figure a medical expert described as "remarkably high," records show.

Narcotics detectives said they were amazed that Kuemmerle was able to prescribe so many drugs undetected for so long, even though state authorities had access to a database that collected a record every time a pharmacy dispensed one.

Kuemmerle could not be reached for comment.

The types of drugs Kuemmerle prescribed are fueling an epidemic of overdose deaths that has drawn the attention of drug enforcement agencies, lawmakers and medical authorities. The response has largely focused on illicit sources of prescription drugs, such as pharmacy robberies and teens stealing from home medicine cabinets.

But a Times investigation of more than 3,700 prescription drug deaths in Southern California found that nearly half of the decedents had a doctor's prescription for one or more of the medications that caused or contributed to their deaths.

The U.S. Centers for Disease Control and Prevention has urged states to mine prescription drug monitoring databases to identify and stop reckless prescribers. At least six states do so. California does not.

lisa.girion@latimes.com

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BlackBerry doesn’t need to catch up with Android and iOS overnight, it needs to live to fight another day

The biggest criticism of BlackBerry’s (RIMM) revamped mobile operating system and smartphone line so far is that they don’t give iOS or Android users any compelling reasons to switch brands. And this is certainly true — BlackBerry 10, for all its virtues, doesn’t do anything significantly better than the top two mobile operating systems and seems designed mostly to please the faithful and not win new converts. At the same time, I think this sort of criticism is based on somewhat unrealistic expectations for what a revamped BlackBerry would be able to achieve in its first iteration. Put simply, making its own loyal fans happy might have been the best that BlackBerry could do in this particular product cycle.

[More from BGR: GS: Ignore the chatter, BlackBerry rebound is coming]

Before we go further with this line of thinking, we should remind ourselves of the truly dire state that BlackBerry CEO Thorsten Heins found the company in when he took it over just over a year ago.

[More from BGR: Here comes the PlayStation 4: Sony announces February 20th PlayStation event [video]]

Longtime customers were fleeing BlackBerry for iOS and Android after BlackBerry repeatedly shot itself in the foot by releasing devices that featured outdated hardware (the first-generation BlackBerry Torch) or that lacked some of the core capabilities that BlackBerry customers had come to expect (the BlackBerry PlayBook and its lack of native corporate email without a “bridge” connection). The company also got caught completely flat-footed by the rise of mobile apps as a vital component of the global smartphone ecosystem and typically wouldn’t get big-name apps on its platform for more than a year after they’d been out on iOS and Android, if at all.

Let’s also recall that when Heins announced last summer that BlackBerry 10 would be delayed until the first quarter of 2013, many of us wondered if the new operating system would ever be released or if the company would simply collapse under the weight of competitive pressures. That Heins has been able to not only get BlackBerry 10 launched but also get more than 100 carriers on board with the new platform is a pretty impressive feat. Add in that Heins has been able to score commitments from some important apps such as Skype, WhatsApp and Amazon Kindle, and you begin to appreciate just how far BlackBerry has come from almost going over the brink.

Of course, none of this is even close to being enough to make BlackBerry a force in the mobile industry anytime soon. But if ardent BlackBerry fans buy up the new BlackBerry 10 handsets and if the company maintains its corporate clients, it may be enough to let the company live to fight another day.

Benedict Evans, a strategy consultant for Enders Analysis, has done some back-of-the-envelope calculations and estimates BlackBerry could sell as many as 20 million BlackBerry 10 smartphones in 2013, although he admits this number could be overly optimistic by as much as 50%. But even if BlackBerry sells just 15 million BB10 phones this year, that could be enough to give the company some breathing room while it works to recruit more app developers and generally improve its new operating system’s functionality.

This is not to say that BlackBerry has an easy road from here — the odds are still very much against it. But just as Rome wasn’t built in a day, no one should have expected BlackBerry to return to its former glory overnight. As much as BlackBerry fans would love to see their favorite devices rise up and crush iOS and Android, that sort of comeback was never in the cards. The best BlackBerry can hope is that they’ve stopped the bleeding and can continue building from here.

This article was originally published on BGR.com

Gadgets News Headlines – Yahoo! News

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Washington wins 3 trophies at NAACP Image Awards

LOS ANGELES (AP) — Kerry Washington was a triple threat at the NAACP Image Awards.

The star of ABC's "Scandal" picked up a trio of trophies at the 44th annual ceremony: outstanding actress in a drama series for "Scandal," supporting actress in a motion picture for "Django Unchained" and the President's Award, which is given in recognition of special achievement and exceptional public service.

"This award does not belong to me," said Washington, who plays a slave separated from her husband in "Django Unchained," as she picked up her first trophy of the evening for her role in the film directed by Quentin Tarantino. "It belongs to our ancestors. We shot this film on a slave plantation, and they were with us along every step of the way."

Washington, who plays crisis management consultant Olivia Pope on "Scandal," serves on President Barack Obama's Committee on the Arts and the Humanities.

Don Cheedle was awarded the outstanding actor in a comedy series trophy for his role as a slick management consultant in Showtime's "House of Lies."

"This doesn't belong just to me, but I am taking it home tonight," joked Cheedle.

A few winners weren't present at the Shrine Auditorium to pick up their trophies, including Denzel Washington for outstanding actor in a motion picture for "Flight," Viola Davis for outstanding actress in a motion picture for "Won't Back Down" and Omar Epps for supporting actor in a drama series for Fox's "House."

"Red Tails," the drama about the Tuskegee Airmen, was honored as outstanding motion picture.

"Look! I beat Quentin Tarantino," beamed "Red Tails" executive producer George Lucas as he accepted the award.

LL Cool J, who was honored as outstanding actor in a drama series for CBS' "NCIS: Los Angeles," dedicated his trophy to fellow nominee Michael Clarke Duncan, "The Green Mile" and "The Finder" actor who died last year.

"I wish his family well," said LL. "Let's give it up for him."

Gladys Knight sang during the in memoriam segment, but the beginning of her performance wasn't heard on the live NBC broadcast because of a technical glitch.

Sidney Poitier presented Harry Belafonte with the Spingarn Award, which honors outstanding achievement by an African American. His honor was followed by a serenade from Wyclef Jean and Common.

Other winners at the ceremony hosted by talk show host Steve Harvey included Loretta Devine as supporting actress in a drama series for "Grey's Anatomy," Cassi Davis as outstanding actress in a comedy series and Lance Gross as outstanding supporting actor in a comedy series for TBS' "Tyler Perry's House of Payne."

The Image Awards are presented annually by the National Association for the Advancement of Colored People, and the group's members select the winners.

___

Online:

http://www.naacpimageawards.net

___

Follow AP Entertainment Writer Derrik J. Lang on Twitter at http://www.twitter.com/derrikjlang

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Ferrol Sams, Doctor Turned Novelist, Dies at 90

Ferrol Sams, a country doctor who started writing fiction in his late 50s and went on to win critical praise and a devoted readership for his humorous and perceptive novels and stories that drew on his medical practice and his rural Southern roots, died on Tuesday at his home in Lafayette, Ga. He was 90.

The cause, said his son Ferrol Sams III, also a doctor, was that he was “slap wore out.”

“He lived a full life,” his son said. “He didn’t leave anything in the tank.”

Dr. Sams grew up on a farm in the rural Piedmont area of Georgia, seven mud-road miles from the nearest town. He was a boy during the Depression; books meant escape and discovery. He read “Robinson Crusoe,” then Mark Twain and Charles Dickens. One of his English professors at Mercer University, in Macon, suggested he consider a career in writing, but he chose another route to examining the human condition: medical school.

When he was 58 — after he had served in World War II, started a medical practice with his wife, raised his four children and stopped devoting so much of his mornings to preparing lessons for Sunday school at the Methodist church — he began writing “Run With the Horsemen,” a novel based on his youth. It was published in 1982.

“In the beginning was the land,” the book begins. “Shortly thereafter was the father.”

In The New York Times Book Review, the novelist Robert Miner wrote, “Mr. Sams’s approach to his hero’s experiences is nicely signaled in these two opening sentences.”

He added: “I couldn’t help associating the gentility, good-humored common sense and pace of this novel with my image of a country doctor spinning yarns. The writing is elegant, reflective and amused. Mr. Sams is a storyteller sure of his audience, in no particular hurry, and gifted with perfect timing.”

Dr. Sams modeled the lead character in “Run With the Horsemen,” Porter Osborne Jr., on himself, and featured him in two more novels, “The Whisper of the River” and “When All the World Was Young,” which followed him into World War II.

Dr. Sams also wrote thinly disguised stories about his life as a physician. In “Epiphany,” he captures the friendship that develops between a literary-minded doctor frustrated by bureaucracy and a patient angry over past racism and injustice.

Ferrol Sams Jr. was born Sept. 26, 1922, in Woolsey, Ga. He received a bachelor’s degree from Mercer in 1942 and his medical degree from Emory University in 1949. In his addition to his namesake, survivors include his wife, Dr. Helen Fletcher Sams; his sons Jim and Fletcher; a daughter, Ellen Nichol; eight grandchildren; and nine great-grandchildren.

Some critics tired of what they called the “folksiness” in Dr. Sams’s books. But he did not write for the critics, he said. In an interview with the Georgia Writers Hall of Fame, Dr. Sams was asked what audience he wrote for. Himself, he said.

“If you lose your sense of awe, or if you lose your sense of the ridiculous, you’ve fallen into a terrible pit,” he added. “The only thing that’s worse is never to have had either.”

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